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Assay Detail

CHEMBL950542

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Functional
Antiproliferative activity against stem cell factor-stimulated human UT7 cells
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type UT7
Confidence 1 — Organism
Curated By Autocuration

Target

UT7 (CHEMBL614057)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases.
Chen N, Bürli RW, Neira S, Hungate R, Zhang D, Yu V, Nguyen Y, Tudor Y, Plant M, Flynn S, Meagher KL, Lee MR, Zhang X, Itano A, Schrag M, Xu Y, Ng GY, Hu E.
Bioorg Med Chem Lett (2008) 18 : 4137 -4141
PubMed 18554909 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.67 9.52
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520718 1 9.52
CHEMBL470483 1 7.96
CHEMBL469883 1 7.96
CHEMBL487864 1 7.92
CHEMBL259247 1 7.92
CHEMBL488834 1 7.85
CHEMBL272902 1 7.75
CHEMBL487431 1 7.64
CHEMBL512840 1 7.52
CHEMBL469882 1 7.51
CHEMBL487863 1 7.24
CHEMBL488833 1 6.84
CHEMBL443902 1 6.12
CHEMBL505394 1 -
CHEMBL487865 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520718 IC50 = 0.3 nM 9.52
CHEMBL470483 IC50 = 11.0 nM 7.96
CHEMBL469883 IC50 = 11.0 nM 7.96
CHEMBL487864 IC50 = 12.0 nM 7.92
CHEMBL259247 IC50 = 12.0 nM 7.92
CHEMBL488834 IC50 = 14.0 nM 7.85
CHEMBL272902 IC50 = 18.0 nM 7.75
CHEMBL487431 IC50 = 23.0 nM 7.64
CHEMBL512840 IC50 = 30.0 nM 7.52
CHEMBL469882 IC50 = 31.0 nM 7.51
CHEMBL487863 IC50 = 57.0 nM 7.24
CHEMBL488833 IC50 = 143.0 nM 6.84
CHEMBL443902 IC50 = 761.0 nM 6.12
CHEMBL505394 Activity - -
CHEMBL487865 Activity - -