Assay Detail
Binding
CHEMBL950610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]12G5 antibody from human wild type CXCR4 expressed in COS7 cells
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| logKi | 2 | - | - |
| Ki | 2 | 6.51 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477121 | — | — | 2 | 6.96 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 2 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477121 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL18442 | PLERIXAFOR | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL18442 | PLERIXAFOR | logKi | = | -6.05 | — | - |
| CHEMBL477121 | — | logKi | = | -6.95 | — | - |