Assay Detail
Binding
CHEMBL950881
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Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.33 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232656 | BX 471 FREE BASE | 2.0 | 1 | 8.26 |
| CHEMBL475748 | — | — | 1 | 7.96 |
| CHEMBL473532 | — | — | 1 | 7.64 |
| CHEMBL473734 | — | — | 1 | 7.30 |
| CHEMBL473531 | — | — | 1 | 6.92 |
| CHEMBL514611 | — | — | 1 | 6.85 |
| CHEMBL454942 | — | — | 1 | 6.57 |
| CHEMBL455162 | — | — | 1 | 6.57 |
| CHEMBL517290 | — | — | 1 | 6.54 |
| CHEMBL454940 | — | — | 1 | 6.27 |
| CHEMBL461590 | — | — | 1 | 6.17 |
| CHEMBL516495 | — | — | 1 | 6.16 |
| CHEMBL462441 | — | — | 1 | 6.14 |
| CHEMBL517261 | — | — | 1 | 5.89 |
| CHEMBL462442 | — | — | 1 | 5.53 |
| CHEMBL509457 | — | — | 1 | 5.44 |
| CHEMBL460535 | — | — | 1 | 5.40 |
| CHEMBL517262 | — | — | 1 | 5.33 |
| CHEMBL462644 | — | — | 1 | 5.24 |
| CHEMBL462650 | — | — | 1 | 4.37 |
| CHEMBL454941 | — | — | 1 | - |
| CHEMBL462611 | — | — | 1 | - |
| CHEMBL517141 | — | — | 1 | - |
| CHEMBL462435 | — | — | 1 | - |
| CHEMBL462612 | — | — | 1 | - |
| CHEMBL515927 | — | — | 1 | - |
| CHEMBL472912 | — | — | 1 | - |
| CHEMBL472711 | — | — | 1 | - |
| CHEMBL460534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232656 | BX 471 FREE BASE | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL475748 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL473532 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL473734 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL473531 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL514611 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL454942 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL455162 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL517290 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL454940 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL461590 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL516495 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL462441 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL517261 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL462442 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL509457 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL460535 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL517262 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL462644 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL462650 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL454941 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL462611 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL517141 | — | IC50 | > | 77000.0 | nM | - |
| CHEMBL462435 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL462612 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL515927 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL472912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL472711 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL460534 | — | IC50 | > | 100000.0 | nM | - |