Assay Detail
Binding
CHEMBL950919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV Tat/TAR complex formation by fluorescence quenching assay
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.67 | 5.99 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481893 | — | — | 1 | 5.99 |
| CHEMBL474844 | — | — | 1 | 5.80 |
| CHEMBL473833 | — | — | 1 | 5.71 |
| CHEMBL125002 | — | — | 1 | 5.66 |
| CHEMBL481558 | — | — | 1 | 5.58 |
| CHEMBL480745 | — | — | 1 | 5.52 |
| CHEMBL473832 | — | — | 1 | 5.42 |
| CHEMBL453110 | — | — | 1 | - |
| CHEMBL510236 | — | — | 1 | - |
| CHEMBL519949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481893 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL474844 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL473833 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL125002 | — | Ki | = | 2180.0 | nM | 5.66 |
| CHEMBL481558 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL480745 | — | Ki | = | 3030.0 | nM | 5.52 |
| CHEMBL473832 | — | Ki | = | 3850.0 | nM | 5.42 |
| CHEMBL453110 | — | Activity | - | — | - | |
| CHEMBL510236 | — | Activity | - | — | - | |
| CHEMBL519949 | — | Activity | - | — | - |