Assay Detail
Binding
CHEMBL951043
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor in pig cortical membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.95 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411437 | — | — | 1 | 6.92 |
| CHEMBL272395 | — | — | 1 | 6.92 |
| CHEMBL270056 | — | — | 1 | 6.54 |
| CHEMBL272396 | — | — | 1 | 6.44 |
| CHEMBL272602 | — | — | 1 | 6.17 |
| CHEMBL405292 | — | — | 1 | 5.92 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.85 |
| CHEMBL272853 | — | — | 1 | 5.85 |
| CHEMBL310843 | — | — | 1 | 5.77 |
| CHEMBL405260 | — | — | 1 | 5.24 |
| CHEMBL407818 | — | — | 1 | 4.92 |
| CHEMBL272873 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411437 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL272395 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL270056 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL272396 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL272602 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL405292 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL7927 | FAUC 113 | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL272853 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL310843 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL405260 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL407818 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL272873 | — | Ki | = | 13000.0 | nM | 4.89 |