Assay Detail
Binding
CHEMBL951045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from adrenergic alpha1 receptor in pig cortical membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.81 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411437 | — | — | 1 | 8.27 |
| CHEMBL272395 | — | — | 1 | 7.68 |
| CHEMBL272602 | — | — | 1 | 7.58 |
| CHEMBL405260 | — | — | 1 | 7.40 |
| CHEMBL407818 | — | — | 1 | 7.09 |
| CHEMBL270056 | — | — | 1 | 7.06 |
| CHEMBL7927 | FAUC 113 | — | 1 | 6.62 |
| CHEMBL272396 | — | — | 1 | 6.62 |
| CHEMBL310843 | — | — | 1 | 6.57 |
| CHEMBL405292 | — | — | 1 | 6.04 |
| CHEMBL272853 | — | — | 1 | 5.39 |
| CHEMBL272873 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411437 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL272395 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL272602 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL405260 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL407818 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL270056 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL7927 | FAUC 113 | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL272396 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL310843 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL405292 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL272853 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL272873 | — | Ki | = | 4500.0 | nM | 5.35 |