Assay Detail
Functional
CHEMBL951050
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Agonist activity at rat dopamine D4.2 receptor expressed in CHO10001A cells assessed as incorporation of [3H]thymidine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.33 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405260 | — | — | 1 | 9.10 |
| CHEMBL411437 | — | — | 1 | 9.00 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.15 |
| CHEMBL272853 | — | — | 1 | 8.04 |
| CHEMBL7927 | FAUC 113 | — | 1 | 7.92 |
| CHEMBL272873 | — | — | 1 | 7.75 |
| CHEMBL310843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405260 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL411437 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL272853 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL7927 | FAUC 113 | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL272873 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL310843 | — | EC50 | - | — | - |