Assay Detail
Binding
CHEMBL951086
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Inhibition of human recombinant Akt2
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rapid assembly of diverse and potent allosteric Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.93 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255835 | — | — | 1 | 7.07 |
| CHEMBL253458 | — | — | 1 | 7.00 |
| CHEMBL258844 | — | — | 1 | 6.68 |
| CHEMBL253457 | — | — | 1 | 6.62 |
| CHEMBL402199 | — | — | 1 | 6.59 |
| CHEMBL401999 | — | — | 1 | 6.56 |
| CHEMBL402579 | — | — | 1 | 6.55 |
| CHEMBL401622 | — | — | 1 | 6.25 |
| CHEMBL270815 | — | — | 1 | 6.24 |
| CHEMBL255360 | — | — | 1 | 6.16 |
| CHEMBL255348 | — | — | 1 | 6.08 |
| CHEMBL255559 | — | — | 1 | 5.91 |
| CHEMBL429576 | — | — | 1 | 5.69 |
| CHEMBL270157 | — | — | 1 | 5.13 |
| CHEMBL270388 | — | — | 1 | 5.13 |
| CHEMBL255772 | — | — | 1 | 5.09 |
| CHEMBL257441 | — | — | 1 | 4.81 |
| CHEMBL362455 | — | — | 1 | 4.64 |
| CHEMBL402355 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255835 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL253458 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL258844 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL253457 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL402199 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL401999 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL402579 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL401622 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL270815 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL255360 | — | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL255348 | — | IC50 | = | 839.0 | nM | 6.08 |
| CHEMBL255559 | — | IC50 | = | 1228.0 | nM | 5.91 |
| CHEMBL429576 | — | IC50 | = | 2062.0 | nM | 5.69 |
| CHEMBL270157 | — | IC50 | = | 7356.0 | nM | 5.13 |
| CHEMBL270388 | — | IC50 | = | 7356.0 | nM | 5.13 |
| CHEMBL255772 | — | IC50 | = | 8141.0 | nM | 5.09 |
| CHEMBL257441 | — | IC50 | = | 15390.0 | nM | 4.81 |
| CHEMBL362455 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL402355 | — | IC50 | = | 37720.0 | nM | 4.42 |