Assay Detail
Binding
CHEMBL951089
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Inhibition of Akt2 phosphorylation in human C33a cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C33a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rapid assembly of diverse and potent allosteric Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.95 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402579 | — | — | 1 | 6.46 |
| CHEMBL253458 | — | — | 1 | 6.33 |
| CHEMBL255835 | — | — | 1 | 5.92 |
| CHEMBL253457 | — | — | 1 | 5.74 |
| CHEMBL402199 | — | — | 1 | 5.29 |
| CHEMBL255360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402579 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL253458 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL255835 | — | IC50 | = | 1198.0 | nM | 5.92 |
| CHEMBL253457 | — | IC50 | = | 1811.0 | nM | 5.74 |
| CHEMBL402199 | — | IC50 | = | 5084.0 | nM | 5.29 |
| CHEMBL255360 | — | IC50 | - | — | - |