Assay Detail
Functional
CHEMBL951135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells after 72 hrs by methylene blue staining
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conformational preferences of natural and C3-modified epothilones in aqueous solution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.94 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | — | 1 | 8.54 |
| CHEMBL411694 | 3-DEOXY-2,3-DIDEHYDRO-EPO A | — | 1 | 8.06 |
| CHEMBL261834 | 3-DEOXY-EPO A | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL411694 | 3-DEOXY-2,3-DIDEHYDRO-EPO A | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL261834 | 3-DEOXY-EPO A | IC50 | = | 58.4 | nM | 7.23 |