Assay Detail
Binding
CHEMBL951280
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Inhibition of KDR
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.37 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272250 | — | — | 1 | 9.43 |
| CHEMBL270342 | — | — | 1 | 9.35 |
| CHEMBL429743 | — | — | 1 | 9.32 |
| CHEMBL272198 | — | — | 1 | 9.22 |
| CHEMBL271984 | — | — | 1 | 9.05 |
| CHEMBL272252 | — | — | 1 | 8.92 |
| CHEMBL260532 | — | — | 1 | 8.89 |
| CHEMBL259252 | — | — | 1 | 8.89 |
| CHEMBL269871 | — | — | 1 | 8.89 |
| CHEMBL409103 | — | — | 1 | 8.89 |
| CHEMBL270556 | — | — | 1 | 8.89 |
| CHEMBL411284 | — | — | 1 | 8.54 |
| CHEMBL410840 | — | — | 1 | 8.42 |
| CHEMBL270754 | — | — | 1 | 8.42 |
| CHEMBL271189 | — | — | 1 | 8.38 |
| CHEMBL408211 | — | — | 1 | 8.23 |
| CHEMBL270755 | — | — | 1 | 7.96 |
| CHEMBL271188 | — | — | 1 | 7.92 |
| CHEMBL428961 | — | — | 1 | 7.82 |
| CHEMBL410903 | — | — | 1 | 7.82 |
| CHEMBL260531 | — | — | 1 | 7.66 |
| CHEMBL272251 | — | — | 1 | 7.55 |
| CHEMBL412278 | — | — | 1 | 6.50 |
| CHEMBL406914 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272250 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL270342 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL429743 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL272198 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL271984 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL272252 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL260532 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL259252 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL269871 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL409103 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL270556 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL411284 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL410840 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL270754 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL271189 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL408211 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL270755 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL271188 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL428961 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL410903 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL260531 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL272251 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL412278 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL406914 | — | IC50 | = | 1500.0 | nM | 5.82 |