Assay Detail
Binding
CHEMBL951284
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora A
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.52 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429743 | — | — | 1 | 6.43 |
| CHEMBL259252 | — | — | 1 | 6.36 |
| CHEMBL428961 | — | — | 1 | 6.25 |
| CHEMBL410903 | — | — | 1 | 6.21 |
| CHEMBL270755 | — | — | 1 | 6.08 |
| CHEMBL410840 | — | — | 1 | 6.03 |
| CHEMBL269871 | — | — | 1 | 5.82 |
| CHEMBL409103 | — | — | 1 | 5.77 |
| CHEMBL272198 | — | — | 1 | 5.70 |
| CHEMBL271189 | — | — | 1 | 5.46 |
| CHEMBL270754 | — | — | 1 | 5.44 |
| CHEMBL408211 | — | — | 1 | 5.44 |
| CHEMBL406914 | — | — | 1 | 5.43 |
| CHEMBL272250 | — | — | 1 | 5.36 |
| CHEMBL271984 | — | — | 1 | 5.30 |
| CHEMBL260532 | — | — | 1 | 5.17 |
| CHEMBL271188 | — | — | 1 | 5.14 |
| CHEMBL411284 | — | — | 1 | 5.08 |
| CHEMBL270556 | — | — | 1 | 5.08 |
| CHEMBL270342 | — | — | 1 | 5.08 |
| CHEMBL272251 | — | — | 1 | 5.08 |
| CHEMBL272252 | — | — | 1 | 5.08 |
| CHEMBL260531 | — | — | 1 | 5.08 |
| CHEMBL412278 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429743 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL259252 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL428961 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL410903 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL270755 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL410840 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL269871 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL409103 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL272198 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL271189 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL270754 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL408211 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL406914 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL272250 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL271984 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL260532 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL271188 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL411284 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL270556 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL270342 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL272251 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL272252 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL260531 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL412278 | — | IC50 | = | 25000.0 | nM | 4.60 |