Assay Detail
Functional
CHEMBL951286
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Inhibition of VEGF-induced proliferation of HUVEC
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.37 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269871 | — | — | 1 | 9.48 |
| CHEMBL270754 | — | — | 1 | 9.35 |
| CHEMBL271188 | — | — | 1 | 9.19 |
| CHEMBL260531 | — | — | 1 | 9.10 |
| CHEMBL272198 | — | — | 1 | 9.04 |
| CHEMBL272250 | — | — | 1 | 8.92 |
| CHEMBL260532 | — | — | 1 | 8.89 |
| CHEMBL271984 | — | — | 1 | 8.68 |
| CHEMBL270342 | — | — | 1 | 8.47 |
| CHEMBL408211 | — | — | 1 | 8.36 |
| CHEMBL410903 | — | — | 1 | 8.18 |
| CHEMBL259252 | — | — | 1 | 8.17 |
| CHEMBL271189 | — | — | 1 | 8.15 |
| CHEMBL411284 | — | — | 1 | 8.14 |
| CHEMBL409103 | — | — | 1 | 8.13 |
| CHEMBL429743 | — | — | 1 | 8.12 |
| CHEMBL272252 | — | — | 1 | 7.80 |
| CHEMBL270556 | — | — | 1 | 7.80 |
| CHEMBL272251 | — | — | 1 | 7.70 |
| CHEMBL270755 | — | — | 1 | 7.66 |
| CHEMBL410840 | — | — | 1 | 7.62 |
| CHEMBL428961 | — | — | 1 | 7.16 |
| CHEMBL406914 | — | — | 1 | - |
| CHEMBL412278 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269871 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL270754 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL271188 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL260531 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL272198 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL272250 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL260532 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL271984 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL270342 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL408211 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL410903 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL259252 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL271189 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL411284 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL409103 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL429743 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL272252 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL270556 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL272251 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL270755 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL410840 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL428961 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL406914 | — | IC50 | - | — | - | |
| CHEMBL412278 | — | IC50 | - | — | - |