Assay Detail
Functional
CHEMBL951287
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Inhibition of bFGF-induced proliferation of HUVEC
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.23 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270754 | — | — | 1 | 7.34 |
| CHEMBL269871 | — | — | 1 | 6.82 |
| CHEMBL272198 | — | — | 1 | 6.77 |
| CHEMBL271984 | — | — | 1 | 6.64 |
| CHEMBL409103 | — | — | 1 | 6.22 |
| CHEMBL429743 | — | — | 1 | 5.94 |
| CHEMBL271189 | — | — | 1 | 5.94 |
| CHEMBL271188 | — | — | 1 | 5.94 |
| CHEMBL410840 | — | — | 1 | 5.94 |
| CHEMBL408211 | — | — | 1 | 5.94 |
| CHEMBL270755 | — | — | 1 | 5.94 |
| CHEMBL428961 | — | — | 1 | 5.94 |
| CHEMBL410903 | — | — | 1 | 5.94 |
| CHEMBL259252 | — | — | 1 | 5.94 |
| CHEMBL406914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270754 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL269871 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL272198 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL271984 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL409103 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL429743 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL271189 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL271188 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL410840 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL408211 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL270755 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL428961 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL410903 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL259252 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL406914 | — | IC50 | - | — | - |