Assay Detail
Binding
CHEMBL951578
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Inhibition of Akt2 phosphorylation by HTRF assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.24 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443661 | — | — | 1 | 8.40 |
| CHEMBL447168 | — | — | 1 | 8.22 |
| CHEMBL448991 | — | — | 1 | 8.05 |
| CHEMBL453586 | — | — | 1 | 7.80 |
| CHEMBL454859 | — | — | 1 | 7.66 |
| CHEMBL502426 | — | — | 1 | 7.64 |
| CHEMBL503980 | — | — | 1 | 7.60 |
| CHEMBL504251 | — | — | 1 | 7.57 |
| CHEMBL454210 | — | — | 1 | 7.54 |
| CHEMBL453995 | — | — | 1 | 7.51 |
| CHEMBL447348 | — | — | 1 | 7.40 |
| CHEMBL488654 | — | — | 1 | 7.37 |
| CHEMBL500993 | — | — | 1 | 7.35 |
| CHEMBL508754 | — | — | 1 | 7.33 |
| CHEMBL448196 | — | — | 1 | 7.23 |
| CHEMBL499683 | — | — | 1 | 7.17 |
| CHEMBL448926 | — | — | 1 | 7.14 |
| CHEMBL450545 | — | — | 1 | 7.11 |
| CHEMBL252456 | — | — | 1 | 7.05 |
| CHEMBL252857 | — | — | 1 | 7.03 |
| CHEMBL442718 | — | — | 1 | 7.03 |
| CHEMBL448826 | — | — | 1 | 6.99 |
| CHEMBL447044 | — | — | 1 | 6.86 |
| CHEMBL505758 | — | — | 1 | 6.81 |
| CHEMBL451961 | — | — | 1 | 6.60 |
| CHEMBL450772 | — | — | 1 | 6.53 |
| CHEMBL506434 | — | — | 1 | 6.27 |
| CHEMBL443633 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443661 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL447168 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL448991 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL453586 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL454859 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL502426 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL503980 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL504251 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL454210 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL453995 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL447348 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL488654 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL500993 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL508754 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL448196 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL499683 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL448926 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL450545 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL252456 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL252857 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL442718 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL448826 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL447044 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL505758 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL451961 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL450772 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL506434 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL443633 | — | IC50 | = | 3570.0 | nM | 5.45 |