Assay Detail
Binding
CHEMBL951580
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Inhibition of Akt2 phosphorylation in human by C33a cells by IPKA assay
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C33a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.82 | 7.72 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447168 | — | — | 1 | 7.72 |
| CHEMBL448991 | — | — | 1 | 7.57 |
| CHEMBL443661 | — | — | 1 | 7.41 |
| CHEMBL453995 | — | — | 1 | 7.39 |
| CHEMBL503980 | — | — | 1 | 7.36 |
| CHEMBL504251 | — | — | 1 | 7.28 |
| CHEMBL454859 | — | — | 1 | 7.16 |
| CHEMBL450545 | — | — | 1 | 7.00 |
| CHEMBL508754 | — | — | 1 | 6.90 |
| CHEMBL448196 | — | — | 1 | 6.88 |
| CHEMBL453586 | — | — | 1 | 6.84 |
| CHEMBL500993 | — | — | 1 | 6.78 |
| CHEMBL447348 | — | — | 1 | 6.75 |
| CHEMBL448826 | — | — | 1 | 6.74 |
| CHEMBL502426 | — | — | 1 | 6.71 |
| CHEMBL454210 | — | — | 1 | 6.70 |
| CHEMBL505758 | — | — | 1 | 6.65 |
| CHEMBL442718 | — | — | 1 | 6.64 |
| CHEMBL488654 | — | — | 1 | 6.61 |
| CHEMBL252456 | — | — | 1 | 6.41 |
| CHEMBL499683 | — | — | 1 | 6.38 |
| CHEMBL451961 | — | — | 1 | 6.33 |
| CHEMBL448926 | — | — | 1 | 6.17 |
| CHEMBL447044 | — | — | 1 | 6.13 |
| CHEMBL252857 | — | — | 1 | 6.05 |
| CHEMBL506434 | — | — | 1 | - |
| CHEMBL443633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447168 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL448991 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL443661 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL453995 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL503980 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL504251 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL454859 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL450545 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL508754 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL448196 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL453586 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL500993 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL447348 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL448826 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL502426 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL454210 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL505758 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL442718 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL488654 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL252456 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL499683 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL451961 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL448926 | — | IC50 | = | 684.0 | nM | 6.17 |
| CHEMBL447044 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL252857 | — | IC50 | = | 899.0 | nM | 6.05 |
| CHEMBL506434 | — | Activity | - | — | - | |
| CHEMBL443633 | — | Activity | - | — | - |