Assay Detail
Binding
CHEMBL952114
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Inhibition of CDK1/Cyclin B
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.54 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115498 | — | — | 1 | 5.22 |
| CHEMBL269881 | — | — | 1 | 5.16 |
| CHEMBL429409 | — | — | 1 | 4.96 |
| CHEMBL407877 | — | — | 1 | 4.96 |
| CHEMBL271593 | — | — | 1 | 4.82 |
| CHEMBL402453 | — | — | 1 | 4.77 |
| CHEMBL405197 | — | — | 1 | 4.72 |
| CHEMBL405259 | — | — | 1 | 4.72 |
| CHEMBL270982 | — | — | 1 | 4.72 |
| CHEMBL269872 | — | — | 1 | 4.68 |
| CHEMBL407874 | 6-O-BENZYLGUANINE | 3.0 | 1 | 4.62 |
| CHEMBL334050 | — | — | 1 | 4.60 |
| CHEMBL259244 | — | — | 1 | 4.57 |
| CHEMBL407876 | — | — | 1 | 4.50 |
| CHEMBL270946 | — | — | 1 | 4.50 |
| CHEMBL405533 | — | — | 1 | 4.44 |
| CHEMBL270979 | — | — | 1 | 4.43 |
| CHEMBL406495 | — | — | 1 | 4.43 |
| CHEMBL429744 | — | — | 1 | 4.41 |
| CHEMBL272872 | — | — | 1 | 4.39 |
| CHEMBL270980 | — | — | 1 | 4.35 |
| CHEMBL446625 | — | — | 1 | 4.23 |
| CHEMBL270945 | — | — | 1 | 4.21 |
| CHEMBL325053 | — | — | 1 | 4.17 |
| CHEMBL271564 | — | — | 1 | 4.12 |
| CHEMBL114250 | — | — | 1 | 4.12 |
| CHEMBL272692 | — | — | 1 | 4.12 |
| CHEMBL270483 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115498 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL269881 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL429409 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL407877 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL271593 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL402453 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL405197 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL405259 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL270982 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL269872 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL407874 | 6-O-BENZYLGUANINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL334050 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL259244 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL407876 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL270946 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL405533 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL270979 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL406495 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL429744 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL272872 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL270980 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL446625 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL270945 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL325053 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL271564 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL114250 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL272692 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL270483 | — | IC50 | = | 91000.0 | nM | 4.04 |