Assay Detail
Binding
CHEMBL952116
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Inhibition of CDK2/Cyclin A
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.45 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115498 | — | — | 1 | 4.89 |
| CHEMBL402453 | — | — | 1 | 4.82 |
| CHEMBL407877 | — | — | 1 | 4.80 |
| CHEMBL269881 | — | — | 1 | 4.77 |
| CHEMBL405197 | — | — | 1 | 4.70 |
| CHEMBL270982 | — | — | 1 | 4.68 |
| CHEMBL271593 | — | — | 1 | 4.68 |
| CHEMBL429409 | — | — | 1 | 4.66 |
| CHEMBL259244 | — | — | 1 | 4.60 |
| CHEMBL269872 | — | — | 1 | 4.58 |
| CHEMBL405259 | — | — | 1 | 4.51 |
| CHEMBL405533 | — | — | 1 | 4.48 |
| CHEMBL334050 | — | — | 1 | 4.47 |
| CHEMBL407876 | — | — | 1 | 4.46 |
| CHEMBL407874 | 6-O-BENZYLGUANINE | 3.0 | 1 | 4.46 |
| CHEMBL270980 | — | — | 1 | 4.38 |
| CHEMBL270979 | — | — | 1 | 4.36 |
| CHEMBL272872 | — | — | 1 | 4.33 |
| CHEMBL270946 | — | — | 1 | 4.32 |
| CHEMBL406495 | — | — | 1 | 4.31 |
| CHEMBL446625 | — | — | 1 | 4.19 |
| CHEMBL429744 | — | — | 1 | 4.19 |
| CHEMBL272692 | — | — | 1 | 4.17 |
| CHEMBL271564 | — | — | 1 | 4.16 |
| CHEMBL114250 | — | — | 1 | 4.12 |
| CHEMBL325053 | — | — | 1 | 4.11 |
| CHEMBL270483 | — | — | 1 | 4.05 |
| CHEMBL270945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115498 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL402453 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL407877 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL269881 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL405197 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL270982 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL271593 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL429409 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL259244 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL269872 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL405259 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL405533 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL334050 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL407876 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL407874 | 6-O-BENZYLGUANINE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL270980 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL270979 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL272872 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL270946 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL406495 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL446625 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL429744 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL272692 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL271564 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL114250 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL325053 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL270483 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL270945 | — | IC50 | > | 100000.0 | nM | - |