Assay Detail
Binding
CHEMBL952234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of calf brain tubulin polymerization
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.65 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL217041 | — | — | 1 | 5.85 |
| CHEMBL330407 | — | — | 1 | 5.58 |
| CHEMBL506431 | — | — | 1 | 5.54 |
| CHEMBL191350 | — | — | 1 | 5.35 |
| CHEMBL496951 | — | — | 1 | - |
| CHEMBL497164 | — | — | 1 | - |
| CHEMBL493948 | — | — | 1 | - |
| CHEMBL496952 | — | — | 1 | - |
| CHEMBL497165 | — | — | 1 | - |
| CHEMBL497166 | — | — | 1 | - |
| CHEMBL495925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL217041 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL330407 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL506431 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL191350 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL496951 | — | IC50 | - | — | - | |
| CHEMBL497164 | — | IC50 | - | — | - | |
| CHEMBL493948 | — | IC50 | - | — | - | |
| CHEMBL496952 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL497165 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL497166 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL495925 | — | IC50 | - | — | - |