Assay Detail
Binding
CHEMBL952241
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Displacement of [3H]des-arg10leu9kallidin from human bradykinin B1 receptor expressed in CHO cells by Wallac beta-plate scintillation counting
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.17 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496530 | — | — | 1 | 9.41 |
| CHEMBL484055 | — | — | 1 | 9.39 |
| CHEMBL521735 | — | — | 1 | 9.32 |
| CHEMBL402831 | — | — | 1 | 9.30 |
| CHEMBL484881 | — | — | 1 | 9.17 |
| CHEMBL484882 | — | — | 2 | 9.17 |
| CHEMBL482829 | — | — | 1 | 9.16 |
| CHEMBL496529 | — | — | 1 | 9.10 |
| CHEMBL483858 | — | — | 1 | 9.02 |
| CHEMBL521454 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496530 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL484055 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL521735 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL402831 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL484881 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL484882 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL482829 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL496529 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL483858 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL484882 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL521454 | — | Ki | = | 1.6 | nM | 8.80 |