Assay Detail
Binding
CHEMBL952393
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Inhibition of lactoperoxidase-catalyzed iodination of L-tyrosine assessed as 3,5-diiodo-L-tyrosine formation by HPLC
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Antithyroid drug carbimazole and its analogues: synthesis and inhibition of peroxidase-catalyzed iodination of L-tyrosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.81 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457523 | — | — | 1 | 5.00 |
| CHEMBL508102 | CARBIMAZOLE | 3.0 | 1 | 4.98 |
| CHEMBL444464 | — | — | 1 | 4.97 |
| CHEMBL1515 | METHIMAZOLE | 4.0 | 1 | 4.93 |
| CHEMBL507966 | — | — | 1 | 4.71 |
| CHEMBL469530 | — | — | 1 | 4.71 |
| CHEMBL469529 | — | — | 1 | 4.69 |
| CHEMBL446332 | — | — | 1 | 4.67 |
| CHEMBL459114 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457523 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL508102 | CARBIMAZOLE | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL444464 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1515 | METHIMAZOLE | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL507966 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL469530 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL469529 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL446332 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL459114 | — | IC50 | = | 25300.0 | nM | 4.60 |