Assay Detail
Binding
CHEMBL952402
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Inhibition of bovine heart mitochondrial complex1 activity
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.48 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606053 | ASIMICIN | — | 1 | 5.92 |
| CHEMBL501110 | — | — | 1 | 5.70 |
| CHEMBL506914 | — | — | 1 | 5.60 |
| CHEMBL1159657 | BULLATACIN | — | 1 | 5.60 |
| CHEMBL499188 | — | — | 1 | 5.52 |
| CHEMBL142918 | rolliniastatin-1 | — | 1 | 5.52 |
| CHEMBL508255 | — | — | 1 | 5.48 |
| CHEMBL451402 | — | — | 1 | 5.30 |
| CHEMBL446085 | — | — | 1 | 5.12 |
| CHEMBL509939 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606053 | ASIMICIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL501110 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL506914 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1159657 | BULLATACIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL499188 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL142918 | rolliniastatin-1 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL508255 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL451402 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL446085 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL509939 | — | IC50 | = | 9000.0 | nM | 5.05 |