Assay Detail
Functional
CHEMBL952476
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Antiviral activity against HBV in adriamycin-resistant HepD2 cells with RTM20V and RTV180M mutation assessed as inhibition of viral DNA replication
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepD2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369673 | — | — | 1 | 7.52 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369673 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL141 | LAMIVUDINE | IC50 | > | 3000.0 | nM | - |