Assay Detail
Functional
CHEMBL952583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL1alpha and oncostatin M-stimulated hydroxyproline release from bovine nasal cartilage
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Tissue | Nasal cartilage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.89 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496942 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496942 | — | IC50 | = | 1300.0 | nM | 5.89 |