Assay Detail
Binding
CHEMBL952768
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Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.38 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258936 | — | — | 1 | 6.72 |
| CHEMBL261773 | — | — | 1 | 6.70 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.52 |
| CHEMBL1201395 | CARBOVIR 5'-TRIPHOSPHATE, (-)- | -1.0 | 1 | 6.05 |
| CHEMBL1236349 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258936 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL261773 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1201395 | CARBOVIR 5'-TRIPHOSPHATE, (-)- | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1236349 | — | IC50 | = | 1300.0 | nM | 5.89 |