Assay Detail
Binding
CHEMBL952869
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Inhibition of Trypanosoma cruzi recombinant squalene synthase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.15 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258717 | — | — | 1 | 9.08 |
| CHEMBL258503 | — | — | 1 | 8.45 |
| CHEMBL259665 | — | — | 1 | 7.30 |
| CHEMBL405590 | — | — | 1 | 6.14 |
| CHEMBL261776 | — | — | 1 | 6.08 |
| CHEMBL406774 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258717 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL258503 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL259665 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL405590 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL261776 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL406774 | — | IC50 | = | 1500.0 | nM | 5.82 |