Assay Detail
Functional
CHEMBL952967
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Antileishmanial activity against Leishmania major MHOM/IL/81/FE/BNI amastigotes after 48 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.84 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260934 | — | — | 1 | 6.22 |
| CHEMBL259289 | — | — | 1 | 6.16 |
| CHEMBL56640 | — | — | 1 | 6.10 |
| CHEMBL264145 | — | — | 1 | 5.52 |
| CHEMBL227559 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260934 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL259289 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL56640 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL264145 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL227559 | — | EC50 | = | 6000.0 | nM | 5.22 |