Assay Detail
Binding
CHEMBL953081
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAMTS4
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4 (CHEMBL2318) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.28 | 5.34 |
| IC50 | 2 | 4.36 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495502 | — | — | 1 | 5.34 |
| CHEMBL207305 | — | — | 1 | 5.34 |
| CHEMBL253275 | — | — | 1 | 5.17 |
| CHEMBL231740 | — | — | 1 | 4.36 |
| CHEMBL401435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495502 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL207305 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL253275 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL231740 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL401435 | — | IC50 | > | 22000.0 | nM | - |