Assay Detail
Binding
CHEMBL953116
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Inhibition of Plk1
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.34 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484473 | — | — | 1 | 7.68 |
| CHEMBL525911 | — | — | 1 | 7.50 |
| CHEMBL496337 | — | — | 1 | 7.38 |
| CHEMBL498190 | — | — | 1 | 7.32 |
| CHEMBL507529 | — | — | 1 | 7.30 |
| CHEMBL498191 | — | — | 1 | 7.23 |
| CHEMBL478028 | — | — | 1 | 6.92 |
| CHEMBL519858 | — | — | 1 | 6.83 |
| CHEMBL497167 | — | — | 1 | 6.68 |
| CHEMBL485295 | — | — | 1 | 6.65 |
| CHEMBL485497 | — | — | 1 | 6.56 |
| CHEMBL508139 | — | — | 1 | 6.38 |
| CHEMBL522392 | — | — | 1 | 6.33 |
| CHEMBL497158 | — | — | 1 | 6.32 |
| CHEMBL485496 | — | — | 1 | 6.19 |
| CHEMBL523233 | — | — | 1 | 6.15 |
| CHEMBL492055 | — | — | 1 | 6.01 |
| CHEMBL525907 | — | — | 1 | 5.89 |
| CHEMBL491850 | — | — | 1 | 5.83 |
| CHEMBL498189 | — | — | 1 | 5.49 |
| CHEMBL496125 | — | — | 1 | 5.34 |
| CHEMBL523423 | — | — | 1 | 5.34 |
| CHEMBL495926 | — | — | 1 | 5.23 |
| CHEMBL496954 | — | — | 1 | 5.11 |
| CHEMBL497159 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484473 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL525911 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL496337 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL498190 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL507529 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL498191 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL478028 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL519858 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL497167 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL485295 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL485497 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL508139 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL522392 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL497158 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL485496 | — | IC50 | = | 641.0 | nM | 6.19 |
| CHEMBL523233 | — | IC50 | = | 703.0 | nM | 6.15 |
| CHEMBL492055 | — | IC50 | = | 977.0 | nM | 6.01 |
| CHEMBL525907 | — | IC50 | = | 1301.0 | nM | 5.89 |
| CHEMBL491850 | — | IC50 | = | 1476.0 | nM | 5.83 |
| CHEMBL498189 | — | IC50 | = | 3241.0 | nM | 5.49 |
| CHEMBL496125 | — | IC50 | = | 4516.0 | nM | 5.34 |
| CHEMBL523423 | — | IC50 | = | 4528.0 | nM | 5.34 |
| CHEMBL495926 | — | IC50 | = | 5928.0 | nM | 5.23 |
| CHEMBL496954 | — | IC50 | = | 7685.0 | nM | 5.11 |
| CHEMBL497159 | — | IC50 | = | 14451.0 | nM | 4.84 |