Assay Detail

CHEMBL953130

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of radiolabeled bombesin from bombesin receptor

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR, Strakhova MI, Vortherms TA, Wakefield BD, Wetter JM, Witte DG, Honore P, Esbenshade TA, Brioni JD, Cowart MD.
J Med Chem (2008) 51 : 7094 -7098
PubMed 18983139 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.74	8.74
IC50	1	8.74	8.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL437027	BOMBESIN	1.0	2	8.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL437027	BOMBESIN	Ki	=	1.8	nM	8.74
CHEMBL437027	BOMBESIN	IC50	=	1.8	nM	8.74