Assay Detail
Binding
CHEMBL953138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled (+)butaclamol from human dopamine D3 receptor
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.85 | 8.85 |
| IC50 | 1 | 8.18 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255588 | — | — | 2 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255588 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1255588 | — | IC50 | = | 6.6 | nM | 8.18 |