Assay Detail
Binding
CHEMBL953271
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Inhibition of PTP SHP1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.73 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453868 | — | — | 1 | 5.22 |
| CHEMBL445194 | — | — | 1 | 5.22 |
| CHEMBL461734 | — | — | 1 | 5.00 |
| CHEMBL455694 | — | — | 1 | 4.82 |
| CHEMBL185726 | — | — | 1 | 4.72 |
| CHEMBL228563 | — | — | 1 | 4.43 |
| CHEMBL228397 | — | — | 1 | 4.29 |
| CHEMBL450560 | — | — | 1 | 4.11 |
| CHEMBL508948 | — | — | 1 | - |
| CHEMBL453899 | — | — | 1 | - |
| CHEMBL453874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453868 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL445194 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL461734 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL455694 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL185726 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL228563 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL228397 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL450560 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL508948 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL453899 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL453874 | — | IC50 | = | 231000.0 | nM | - |