Assay Detail
Binding
CHEMBL953272
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Inhibition of PTP YOP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.75 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453868 | — | — | 1 | 5.30 |
| CHEMBL445194 | — | — | 1 | 5.30 |
| CHEMBL455694 | — | — | 1 | 5.00 |
| CHEMBL461734 | — | — | 1 | 4.92 |
| CHEMBL185726 | — | — | 1 | 4.89 |
| CHEMBL450560 | — | — | 1 | 4.36 |
| CHEMBL508948 | — | — | 1 | 4.21 |
| CHEMBL453899 | — | — | 1 | 4.04 |
| CHEMBL453874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453868 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL445194 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL455694 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL461734 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL185726 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL450560 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL508948 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL453899 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL453874 | — | IC50 | = | 175000.0 | nM | - |