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Assay Detail

CHEMBL953273

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of YPTP1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Shrestha S, Bhattarai BR, Kafle B, Lee KH, Cho H.
Bioorg Med Chem (2008) 16 : 8643 -8652
PubMed 18722777 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.68 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL453868 1 5.16
CHEMBL445194 1 5.00
CHEMBL455694 1 4.89
CHEMBL185726 1 4.70
CHEMBL461734 1 4.68
CHEMBL450560 1 4.23
CHEMBL228563 1 4.07
CHEMBL453874 1 -
CHEMBL228397 1 -
CHEMBL508948 1 -
CHEMBL453899 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL453868 IC50 = 7000.0 nM 5.16
CHEMBL445194 IC50 = 10000.0 nM 5.00
CHEMBL455694 IC50 = 13000.0 nM 4.89
CHEMBL185726 IC50 = 20000.0 nM 4.70
CHEMBL461734 IC50 = 21000.0 nM 4.68
CHEMBL450560 IC50 = 59000.0 nM 4.23
CHEMBL228563 IC50 = 86000.0 nM 4.07
CHEMBL453874 IC50 = 370000.0 nM -
CHEMBL228397 IC50 = 234000.0 nM -
CHEMBL508948 IC50 = 114000.0 nM -
CHEMBL453899 IC50 = 153000.0 nM -