Assay Detail
Binding
CHEMBL953365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Pim1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.19 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183906 | — | — | 1 | 5.52 |
| CHEMBL526468 | — | — | 1 | 5.30 |
| CHEMBL496381 | — | — | 1 | 5.00 |
| CHEMBL526289 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183906 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL526468 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL496381 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL526289 | — | IC50 | = | 12000.0 | nM | 4.92 |