Assay Detail
Functional
CHEMBL953527
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of curcumin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.09 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492966 | — | — | 1 | 5.68 |
| CHEMBL522858 | — | — | 1 | 5.62 |
| CHEMBL522882 | — | — | 1 | 5.60 |
| CHEMBL423698 | — | — | 1 | 5.54 |
| CHEMBL493001 | — | — | 1 | 5.44 |
| CHEMBL128729 | — | — | 1 | 5.41 |
| CHEMBL521819 | — | — | 1 | 5.34 |
| CHEMBL493002 | — | — | 1 | 5.29 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 5.25 |
| CHEMBL495184 | — | — | 1 | 5.23 |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | 5.23 |
| CHEMBL522664 | — | — | 1 | 5.21 |
| CHEMBL494170 | — | — | 1 | 5.13 |
| CHEMBL494234 | — | — | 1 | 5.12 |
| CHEMBL129134 | — | — | 1 | 5.02 |
| CHEMBL494409 | — | — | 1 | 4.89 |
| CHEMBL494169 | — | — | 1 | 4.88 |
| CHEMBL492807 | — | — | 1 | 4.79 |
| CHEMBL493990 | — | — | 1 | 4.71 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.70 |
| CHEMBL494826 | METHYLCURCUMIN | — | 1 | 4.68 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | 4.56 |
| CHEMBL209219 | — | — | 1 | 4.43 |
| CHEMBL492977 | — | — | 1 | 4.40 |
| CHEMBL211338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492966 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL522858 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL522882 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL423698 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL493001 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL128729 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL521819 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL493002 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL495184 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL522664 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL494170 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL494234 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL129134 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL494409 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL494169 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL492807 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL493990 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL140 | CURCUMIN | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL494826 | METHYLCURCUMIN | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL209219 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL492977 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL211338 | — | IC50 | > | 40000.0 | nM | - |