Assay Detail
Functional
CHEMBL953530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of curcumin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.29 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522858 | — | — | 1 | 6.22 |
| CHEMBL492966 | — | — | 1 | 6.22 |
| CHEMBL522882 | — | — | 1 | 5.82 |
| CHEMBL423698 | — | — | 1 | 5.80 |
| CHEMBL522664 | — | — | 1 | 5.77 |
| CHEMBL521819 | — | — | 1 | 5.62 |
| CHEMBL493001 | — | — | 1 | 5.57 |
| CHEMBL128729 | — | — | 1 | 5.55 |
| CHEMBL495184 | — | — | 1 | 5.51 |
| CHEMBL494234 | — | — | 1 | 5.51 |
| CHEMBL129134 | — | — | 1 | 5.41 |
| CHEMBL493002 | — | — | 1 | 5.38 |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | 5.31 |
| CHEMBL494169 | — | — | 1 | 5.26 |
| CHEMBL494170 | — | — | 1 | 5.19 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 5.18 |
| CHEMBL494826 | METHYLCURCUMIN | — | 1 | 5.14 |
| CHEMBL494409 | — | — | 1 | 4.91 |
| CHEMBL493990 | — | — | 1 | 4.84 |
| CHEMBL492807 | — | — | 1 | 4.69 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | 4.66 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.59 |
| CHEMBL492977 | — | — | 1 | 4.50 |
| CHEMBL209219 | — | — | 1 | 4.38 |
| CHEMBL211338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522858 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL492966 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL522882 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL423698 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL522664 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL521819 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL493001 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL128729 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL495184 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL494234 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL129134 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL493002 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL494169 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL494170 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL494826 | METHYLCURCUMIN | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL494409 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL493990 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL492807 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL140 | CURCUMIN | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL492977 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL209219 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL211338 | — | IC50 | > | 40000.0 | nM | - |