Assay Detail
Functional
CHEMBL953570
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Antagonist activity at human 5HT3 receptor by calcium influx assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.40 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499536 | — | — | 1 | 4.70 |
| CHEMBL459689 | — | — | 1 | 4.60 |
| CHEMBL503427 | — | — | 1 | 4.30 |
| CHEMBL459900 | — | — | 1 | 4.00 |
| CHEMBL454407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499536 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL459689 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL503427 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL459900 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL454407 | — | IC50 | = | 251188.64 | nM | - |