Assay Detail
Binding
CHEMBL953930
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Protection against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells assessed as change in viability after 24 hrs by WST1 dye reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7463 | GF-109203 | — | 1 | 5.82 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | — | 1 | 5.64 |
| CHEMBL633 | AMIODARONE | 4.0 | 1 | 5.46 |
| CHEMBL1008 | BEPRIDIL | 4.0 | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7463 | GF-109203 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL322333 | DIMETHYLSPINGOSINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL633 | AMIODARONE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1008 | BEPRIDIL | IC50 | = | 4800.0 | nM | 5.32 |