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Assay Detail

CHEMBL953973

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55940 from human CB1 receptor
ChEMBL ↗
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL218) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel benzimidazole derivatives as selective CB2 agonists.
Pagé D, Balaux E, Boisvert L, Liu Z, Milburn C, Tremblay M, Wei Z, Woo S, Luo X, Cheng YX, Yang H, Srivastava S, Zhou F, Brown W, Tomaszewski M, Walpole C, Hodzic L, St-Onge S, Godbout C, Salois D, Payza K.
Bioorg Med Chem Lett (2008) 18 : 3695 -3700
PubMed 18522867 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 52 5.97 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL465 DRONABINOL 4.0 1 8.54
CHEMBL470965 — — 1 6.96
CHEMBL188 WIN-552122 — 1 6.85
CHEMBL511134 — — 1 6.39
CHEMBL471129 — — 1 6.31
CHEMBL471374 — — 1 5.92
CHEMBL510072 — — 1 5.62
CHEMBL518206 — — 1 5.61
CHEMBL507572 — — 1 5.58
CHEMBL472506 — — 1 5.51
CHEMBL458142 — — 1 5.46
CHEMBL511021 — — 1 5.38
CHEMBL488310 — — 1 5.37
CHEMBL510854 — — 1 5.34
CHEMBL453846 — — 1 5.33
CHEMBL471992 — — 1 5.32
CHEMBL486440 — — 1 -
CHEMBL469693 — — 1 -
CHEMBL512886 — — 1 -
CHEMBL471558 — — 1 -
CHEMBL472121 — — 1 -
CHEMBL471984 — — 1 -
CHEMBL512906 — — 1 -
CHEMBL472165 — — 1 -
CHEMBL472157 — — 1 -
CHEMBL487456 — — 1 -
CHEMBL454607 — — 1 -
CHEMBL462533 — — 1 -
CHEMBL462330 — — 1 -
CHEMBL462329 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL465 DRONABINOL Ki = 2.9 nM 8.54
CHEMBL470965 — Ki = 110.0 nM 6.96
CHEMBL188 WIN-552122 Ki = 140.0 nM 6.85
CHEMBL511134 — Ki = 406.0 nM 6.39
CHEMBL471129 — Ki = 491.0 nM 6.31
CHEMBL471374 — Ki = 1209.0 nM 5.92
CHEMBL510072 — Ki = 2396.0 nM 5.62
CHEMBL518206 — Ki = 2483.0 nM 5.61
CHEMBL507572 — Ki = 2608.0 nM 5.58
CHEMBL472506 — Ki = 3115.0 nM 5.51
CHEMBL458142 — Ki = 3475.0 nM 5.46
CHEMBL511021 — Ki = 4190.0 nM 5.38
CHEMBL488310 — Ki = 4315.0 nM 5.37
CHEMBL510854 — Ki = 4534.0 nM 5.34
CHEMBL453846 — Ki = 4679.0 nM 5.33
CHEMBL471992 — Ki = 4766.0 nM 5.32
CHEMBL518814 — Ki > 5000.0 nM -
CHEMBL461920 — Ki > 5000.0 nM -
CHEMBL453843 — Ki > 5000.0 nM -
CHEMBL453842 — Ki > 5000.0 nM -
CHEMBL453844 — Ki > 5000.0 nM -
CHEMBL454864 — Ki > 5000.0 nM -
CHEMBL471980 — Ki > 5000.0 nM -
CHEMBL510141 — Ki > 5000.0 nM -
CHEMBL454096 — Ki > 5000.0 nM -
CHEMBL452039 — Ki > 5000.0 nM -
CHEMBL451779 — Ki > 5000.0 nM -
CHEMBL452804 — Ki > 5000.0 nM -
CHEMBL452803 — Ki > 5000.0 nM -
CHEMBL453847 — Ki > 5000.0 nM -
CHEMBL487629 — Ki > 5000.0 nM -
CHEMBL486438 — Ki > 5000.0 nM -
CHEMBL488816 — Ki > 5000.0 nM -
CHEMBL472157 — Ki > 5000.0 nM -
CHEMBL486440 — Ki > 5000.0 nM -
CHEMBL469693 — Ki > 5000.0 nM -
CHEMBL512886 — Ki > 5000.0 nM -
CHEMBL471558 — Ki > 5000.0 nM -
CHEMBL472121 — Ki > 5000.0 nM -
CHEMBL471984 — Ki > 5000.0 nM -
CHEMBL512906 — Ki > 5000.0 nM -
CHEMBL472165 — Ki > 5000.0 nM -
CHEMBL461921 — Ki > 5000.0 nM -
CHEMBL487456 — Ki > 5000.0 nM -
CHEMBL454607 — Ki > 5000.0 nM -
CHEMBL462533 — Ki > 5000.0 nM -
CHEMBL462330 — Ki > 5000.0 nM -
CHEMBL462329 — Ki > 5000.0 nM -
CHEMBL517283 — Ki > 5000.0 nM -
CHEMBL462119 — Ki > 5000.0 nM -