Assay Detail
Functional
CHEMBL953993
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Cytotoxicity against human SKBr3 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.11 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486081 | — | — | 1 | 5.70 |
| CHEMBL488127 | — | — | 1 | 5.70 |
| CHEMBL488954 | — | — | 1 | 5.30 |
| CHEMBL488757 | — | — | 1 | 5.30 |
| CHEMBL486706 | — | — | 1 | 5.10 |
| CHEMBL518923 | — | — | 1 | 5.05 |
| CHEMBL486089 | — | — | 1 | 5.05 |
| CHEMBL487936 | — | — | 1 | 4.85 |
| CHEMBL444428 | — | — | 1 | 4.85 |
| CHEMBL450213 | — | — | 1 | 4.82 |
| CHEMBL529448 | — | — | 1 | 4.82 |
| CHEMBL487736 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486081 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL488127 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL488954 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL488757 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL486706 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL518923 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL486089 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL487936 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL444428 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL450213 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL529448 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL487736 | — | IC50 | = | 16000.0 | nM | 4.80 |