Assay Detail
Functional
CHEMBL954074
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Antagonist activity at rat CB1 receptor in SF9 cells assessed as inhibition of CP-55940-stimulated GTPgammaS binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminopyrazine CB1 receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.17 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 9.51 |
| CHEMBL497557 | — | — | 1 | 9.39 |
| CHEMBL496091 | — | — | 1 | 9.08 |
| CHEMBL498783 | — | — | 1 | 8.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL497557 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL496091 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL498783 | — | Ki | = | 2.06 | nM | 8.69 |