Assay Detail
Binding
CHEMBL954222
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Degradation promoting activity of FLAG tagged cIAP1 expressed in human HT1080 cells after 3 hrs by Western blotting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HT-1080 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 3 (CHEMBL5335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.87 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457092 | BESTATIN METHYL ESTER | — | 1 | 6.16 |
| CHEMBL526858 | — | — | 1 | 5.73 |
| CHEMBL454988 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457092 | BESTATIN METHYL ESTER | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL526858 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL454988 | — | IC50 | = | 1890.0 | nM | 5.72 |