Assay Detail
Binding
CHEMBL954255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 reverse transcriptase p66/p51
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.71 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85059 | — | — | 1 | 9.52 |
| CHEMBL502565 | — | — | 1 | 9.40 |
| CHEMBL470007 | — | — | 1 | 9.40 |
| CHEMBL470630 | — | — | 1 | 8.70 |
| CHEMBL398174 | — | — | 1 | 8.52 |
| CHEMBL502566 | — | — | 1 | 8.52 |
| CHEMBL383700 | — | — | 1 | 8.00 |
| CHEMBL511961 | — | — | 1 | 7.89 |
| CHEMBL471660 | — | — | 1 | 7.80 |
| CHEMBL469562 | — | — | 1 | 7.80 |
| CHEMBL469769 | — | — | 1 | 7.77 |
| CHEMBL127012 | — | — | 1 | 7.70 |
| CHEMBL511290 | — | — | 1 | 7.66 |
| CHEMBL470404 | — | — | 1 | 7.60 |
| CHEMBL512132 | — | — | 1 | 7.58 |
| CHEMBL126603 | — | — | 1 | 7.58 |
| CHEMBL512673 | — | — | 1 | 7.58 |
| CHEMBL469985 | — | — | 1 | 7.57 |
| CHEMBL472217 | — | — | 1 | 7.57 |
| CHEMBL485180 | — | — | 1 | 7.55 |
| CHEMBL512486 | — | — | 1 | 7.48 |
| CHEMBL513080 | — | — | 1 | 7.47 |
| CHEMBL470403 | — | — | 1 | 7.47 |
| CHEMBL521183 | — | — | 1 | 7.44 |
| CHEMBL511963 | — | — | 1 | 7.21 |
| CHEMBL524360 | — | — | 1 | 7.21 |
| CHEMBL469569 | — | — | 1 | 7.09 |
| CHEMBL469986 | — | — | 1 | 7.07 |
| CHEMBL469358 | — | — | 1 | 6.92 |
| CHEMBL471867 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85059 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL502565 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL470007 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL470630 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL398174 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL502566 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL383700 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL511961 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL471660 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL469562 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL469769 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL127012 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL511290 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL470404 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL126603 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL512673 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL512132 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL469985 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL472217 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL485180 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL512486 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL513080 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL470403 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL521183 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL511963 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL524360 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL469569 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL469986 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL469358 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL471867 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL512176 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL469804 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL502297 | — | IC50 | - | — | - |