Assay Detail
Binding
CHEMBL954256
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Inhibition of HIV1 reverse transcriptase p66/p51 L100I mutant
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398174 | — | — | 1 | 8.70 |
| CHEMBL502565 | — | — | 1 | 8.40 |
| CHEMBL470630 | — | — | 1 | 7.89 |
| CHEMBL470007 | — | — | 1 | 7.60 |
| CHEMBL469562 | — | — | 1 | 7.39 |
| CHEMBL85059 | — | — | 1 | 7.22 |
| CHEMBL127012 | — | — | 1 | 6.95 |
| CHEMBL502566 | — | — | 1 | 6.90 |
| CHEMBL513080 | — | — | 1 | 6.89 |
| CHEMBL469985 | — | — | 1 | 6.84 |
| CHEMBL126603 | — | — | 1 | 6.79 |
| CHEMBL469986 | — | — | 1 | 6.77 |
| CHEMBL512486 | — | — | 1 | 6.72 |
| CHEMBL512673 | — | — | 1 | 6.70 |
| CHEMBL472217 | — | — | 1 | 6.69 |
| CHEMBL470403 | — | — | 1 | 6.69 |
| CHEMBL511290 | — | — | 1 | 6.68 |
| CHEMBL469358 | — | — | 1 | 6.60 |
| CHEMBL511963 | — | — | 1 | 6.57 |
| CHEMBL521183 | — | — | 1 | 6.57 |
| CHEMBL469569 | — | — | 1 | 6.53 |
| CHEMBL470404 | — | — | 1 | 6.50 |
| CHEMBL485180 | — | — | 1 | 6.44 |
| CHEMBL469804 | — | — | 1 | 6.41 |
| CHEMBL524360 | — | — | 1 | 6.41 |
| CHEMBL502297 | — | — | 1 | - |
| CHEMBL383700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398174 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL502565 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL470630 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL470007 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL469562 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL85059 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL127012 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL502566 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL513080 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL469985 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL126603 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL469986 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL512486 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL512673 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL472217 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL470403 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL511290 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL469358 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL511963 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL521183 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL469569 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL470404 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL485180 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL469804 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL524360 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL502297 | — | IC50 | - | — | - | |
| CHEMBL383700 | — | IC50 | - | — | - |