Assay Detail
Binding
CHEMBL954257
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Inhibition of HIV1 reverse transcriptase p66/p51 K103N mutant
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.39 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85059 | — | — | 1 | 8.52 |
| CHEMBL521183 | — | — | 1 | 8.52 |
| CHEMBL398174 | — | — | 1 | 8.22 |
| CHEMBL127012 | — | — | 1 | 6.72 |
| CHEMBL502565 | — | — | 1 | 6.63 |
| CHEMBL469769 | — | — | 1 | 6.60 |
| CHEMBL126603 | — | — | 1 | 6.55 |
| CHEMBL469358 | — | — | 1 | 6.54 |
| CHEMBL469569 | — | — | 1 | 6.49 |
| CHEMBL471660 | — | — | 1 | 6.49 |
| CHEMBL469985 | — | — | 1 | 6.46 |
| CHEMBL511290 | — | — | 1 | 6.44 |
| CHEMBL469986 | — | — | 1 | 6.38 |
| CHEMBL470403 | — | — | 1 | 6.38 |
| CHEMBL472217 | — | — | 1 | 6.32 |
| CHEMBL469562 | — | — | 1 | 6.29 |
| CHEMBL470630 | — | — | 1 | 6.28 |
| CHEMBL470007 | — | — | 1 | 6.23 |
| CHEMBL512673 | — | — | 1 | 6.11 |
| CHEMBL513080 | — | — | 1 | 6.11 |
| CHEMBL524360 | — | — | 1 | 6.10 |
| CHEMBL383700 | — | — | 1 | 6.10 |
| CHEMBL512132 | — | — | 1 | 6.00 |
| CHEMBL470404 | — | — | 1 | 5.98 |
| CHEMBL512486 | — | — | 1 | 5.96 |
| CHEMBL502566 | — | — | 1 | 5.88 |
| CHEMBL512176 | — | — | 1 | 5.87 |
| CHEMBL471867 | — | — | 1 | 5.85 |
| CHEMBL511963 | — | — | 1 | 5.82 |
| CHEMBL511961 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85059 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL521183 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL398174 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL127012 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL502565 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL469769 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL126603 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL469358 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL469569 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL471660 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL469985 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL511290 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL469986 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL470403 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL472217 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL469562 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL470630 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL470007 | — | IC50 | = | 584.0 | nM | 6.23 |
| CHEMBL512673 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL513080 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL524360 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL383700 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL512132 | — | IC50 | = | 1005.0 | nM | 6.00 |
| CHEMBL470404 | — | IC50 | = | 1042.0 | nM | 5.98 |
| CHEMBL512486 | — | IC50 | = | 1088.0 | nM | 5.96 |
| CHEMBL502566 | — | IC50 | = | 1328.0 | nM | 5.88 |
| CHEMBL512176 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL471867 | — | IC50 | = | 1417.0 | nM | 5.85 |
| CHEMBL511963 | — | IC50 | = | 1522.0 | nM | 5.82 |
| CHEMBL511961 | — | IC50 | = | 1504.0 | nM | 5.82 |
| CHEMBL485180 | — | IC50 | = | 3277.0 | nM | 5.49 |
| CHEMBL469804 | — | IC50 | = | 3387.0 | nM | 5.47 |
| CHEMBL502297 | — | IC50 | - | — | - |