Assay Detail
Functional
CHEMBL954317
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Cytotoxicity against human HepG2 cells by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.75 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445086 | ASCLEPIN | — | 1 | 7.70 |
| CHEMBL495949 | CALOTROPIN | — | 1 | 7.40 |
| CHEMBL449207 | USCHARIDIN | — | 1 | 6.42 |
| CHEMBL447912 | — | — | 1 | 6.16 |
| CHEMBL454779 | — | — | 1 | 6.12 |
| CHEMBL448662 | — | — | 1 | 5.87 |
| CHEMBL471686 | — | — | 1 | 5.52 |
| CHEMBL522203 | — | — | 1 | 5.29 |
| CHEMBL495179 | COROGLAUCIGENIN | — | 1 | 5.17 |
| CHEMBL449767 | DESGLUCOUZARIN | — | 1 | 5.07 |
| CHEMBL495033 | CALOTROPAGENIN | — | 1 | 4.25 |
| CHEMBL493006 | — | — | 1 | 4.05 |
| CHEMBL510977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445086 | ASCLEPIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL495949 | CALOTROPIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL449207 | USCHARIDIN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL447912 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL454779 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL448662 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL471686 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL522203 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL495179 | COROGLAUCIGENIN | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL449767 | DESGLUCOUZARIN | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL495033 | CALOTROPAGENIN | IC50 | = | 56610.0 | nM | 4.25 |
| CHEMBL493006 | — | IC50 | = | 89930.0 | nM | 4.05 |
| CHEMBL510977 | — | IC50 | > | 100000.0 | nM | - |