Assay Detail
Functional
CHEMBL954344
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction in leutinizing hormone release in (D-Trp6)-GnRH-stimulated rat primary pituitary cells by RIA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.63 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460480 | — | — | 1 | 7.23 |
| CHEMBL521674 | — | — | 1 | 6.70 |
| CHEMBL493344 | — | — | 1 | 6.62 |
| CHEMBL494400 | — | — | 1 | 6.60 |
| CHEMBL493731 | — | — | 1 | 6.53 |
| CHEMBL492327 | — | — | 1 | 6.52 |
| CHEMBL493565 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460480 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL521674 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL493344 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL494400 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL493731 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL492327 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL493565 | — | IC50 | = | 570.0 | nM | 6.24 |