Assay Detail
Functional
CHEMBL954846
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.64 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144037 | — | — | 1 | 8.22 |
| CHEMBL485881 | — | — | 1 | 8.15 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.96 |
| CHEMBL448846 | — | — | 1 | 7.92 |
| CHEMBL356292 | — | — | 1 | 7.92 |
| CHEMBL317364 | — | — | 1 | 7.89 |
| CHEMBL519708 | — | — | 1 | 7.75 |
| CHEMBL486502 | — | — | 1 | 7.72 |
| CHEMBL486501 | — | — | 1 | 7.68 |
| CHEMBL146333 | — | — | 1 | 7.54 |
| CHEMBL519493 | — | — | 1 | 7.14 |
| CHEMBL484296 | — | — | 1 | 7.03 |
| CHEMBL147802 | — | — | 1 | 7.01 |
| CHEMBL528101 | — | — | 1 | 5.83 |
| CHEMBL519636 | — | — | 1 | 5.73 |
| CHEMBL488146 | — | — | 1 | 5.63 |
| CHEMBL482469 | — | — | 1 | 5.54 |
| CHEMBL482470 | — | — | 1 | 5.51 |
| CHEMBL443725 | — | — | 1 | 5.29 |
| CHEMBL488145 | — | — | 1 | 5.25 |
| CHEMBL216926 | — | — | 1 | 5.24 |
| CHEMBL488359 | — | — | 1 | 5.22 |
| CHEMBL341638 | — | — | 1 | 5.13 |
| CHEMBL502643 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144037 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL485881 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL448846 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL356292 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL317364 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL519708 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL486502 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL486501 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL146333 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL519493 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL484296 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL147802 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL528101 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL519636 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL488146 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL482469 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL482470 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL443725 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL488145 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL216926 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL488359 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL341638 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL502643 | — | IC50 | = | 9530.0 | nM | 5.02 |