Assay Detail
Functional
CHEMBL954847
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.22 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144037 | — | — | 1 | 7.58 |
| CHEMBL317364 | — | — | 1 | 7.58 |
| CHEMBL448846 | — | — | 1 | 7.09 |
| CHEMBL147802 | — | — | 1 | 7.07 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.94 |
| CHEMBL485881 | — | — | 1 | 6.94 |
| CHEMBL356292 | — | — | 1 | 6.70 |
| CHEMBL519493 | — | — | 1 | 6.50 |
| CHEMBL146333 | — | — | 1 | 6.45 |
| CHEMBL484296 | — | — | 1 | 6.39 |
| CHEMBL519708 | — | — | 1 | 6.19 |
| CHEMBL486501 | — | — | 1 | 6.11 |
| CHEMBL486502 | — | — | 1 | 6.01 |
| CHEMBL519636 | — | — | 1 | 6.00 |
| CHEMBL488146 | — | — | 1 | 5.97 |
| CHEMBL482469 | — | — | 1 | 5.93 |
| CHEMBL528101 | — | — | 1 | 5.89 |
| CHEMBL488145 | — | — | 1 | 5.58 |
| CHEMBL443725 | — | — | 1 | 5.55 |
| CHEMBL488359 | — | — | 1 | 5.39 |
| CHEMBL482470 | — | — | 1 | 5.38 |
| CHEMBL341638 | — | — | 1 | 5.35 |
| CHEMBL216926 | — | — | 1 | 5.34 |
| CHEMBL502643 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144037 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL317364 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL448846 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL147802 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL485881 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL356292 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL519493 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL146333 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL484296 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL519708 | — | IC50 | = | 649.0 | nM | 6.19 |
| CHEMBL486501 | — | IC50 | = | 786.0 | nM | 6.11 |
| CHEMBL486502 | — | IC50 | = | 982.0 | nM | 6.01 |
| CHEMBL519636 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL488146 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL482469 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL528101 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL488145 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL443725 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL488359 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL482470 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL341638 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL216926 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL502643 | — | IC50 | = | 5500.0 | nM | 5.26 |